Which substance is most abundant in the extracellular matrix of connective tissues?

The most abundant substance in the extracellular matrix of connective tissues is collagen. Collagen is a structural protein that forms a significant part of the matrix and provides strength and support to various tissues and organs. It is crucial for maintaining the integrity and resilience of connective tissues, such as tendons, ligaments, cartilage, and dermis of the skin.

Collagen fibers are organized in a way that allows them to withstand tension and provide a scaffold for tissue structure. This makes collagen essential for the mechanical properties of tissues, aiding in their ability to bear weight and resist stretching.

While water is prevalent in connective tissues and plays an important role in hydration and nutrient transport, it does not provide structural strength like collagen does. Other proteins and minerals also contribute to the extracellular matrix composition, but collagen remains the primary and most abundant component in terms of its structural role.